MIT 6.874/6.802/20.390/20.490/HST.506 Spring 2021 Prof. Manolis Kellis
Deep Learning in the Life Sciences / Computational Systems Biology
Playlist:    • MIT Deep Learning in Life Sciences - ...  
Latest slides and course today: http://compbio.mit.edu/6874
Spring 2021 slides and materials: http://mit6874.github.io/

00:00 Introduction
02:54 Inheritance
12:54 Genetic variation
19:15 Common and rare variants
23:34 Linkage analysis
25:25 GWAS
42:50 GWAS for Crohn's disease
46:35 Linkage disequilibrium
48:55 Case study: FTO and obesity
1:02:00 Learning the sequence-based regulatory programs of the genome
1:08:56 Predicting the effect of variants
1:17:14 Predicting gene expression from sequence
1:21:12 Detecting Autism noncoding de novo mutation contribution