Why is Alex Garland's Annihilation so creep and unpleasant, yet beautiful and elegant? What makes it feel so...alien? Well, a lot of it has to do with how the film builds up its cosmic 'off-ness', and at the center of it all is this one shot composition: a frame within a frame shot.
Let's take a look.
(Also, of course, the original material is masterful so that helps)

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Extra Credits:

A read on 'frame within a frame' shot:
https://photographycourse.net/frame-w...

Sound from http://www.freesound.org/people/klank...

Timestamp
0:00 Introduction
1:07 The one shot
2:36 The three types
3:34 Accumulation
4:04 i. Uncanny
4:32 Deviation
5:27 ii. Stalker
6:23 Past vs Present
6:48 Set Design
7:40 Light Setup
8:20 iii. The Light
9:08 Invitation
9:53 iv. The Big Bang
10:14 Humanoid
10:30 Force
10:57 Last Act
12:05 Inevitability
13:14 The Beautiful Terror
14:09 The Moment
14:26 Real Annihilation
15:21 Thank You