Central synapses dynamically direct the flow of action potential signaling through neuronal circuits, thereby regulating brain functions. Synaptic transmission relies on chemical neurotransmitters, which are concentrated in presynaptic vesicles and released by exocytosis. To maintain neurotransmission, vesicles are continuously recycled and refilled with transmitter, a process that consumes most of the ATP provided to the brain. In the past half century, I have explored the fundamental regulatory mechanisms of synaptic transmission. Towards the terminal of my research track, I tackled the underlying causes of synaptic dysfunctions and luckily reached a promising platform, providing new possibilities for the treatment of brain diseases.

The Provost Lecture Series will provide an opportunity to celebrate milestones in the careers of OIST faculty members. It will recognize newly promoted professors and those who have received prestigious awards. It will highlight faculty achievements and create a space for retiring professors to talk about their research accomplishments and lessons learned over the course of their career. It is a way to celebrate OIST faculty, introduce them to the broader OIST community, acknowledge their research successes, share about their teaching and mentorship of students, and honor their service to the university.