The 6 Most Common Causes Of Foot & Ankle Swelling + 6 Amazing Remedies To Fix It!
Diabetes Smarts Program Diabetes Smarts Program
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 Published On Jan 21, 2024

What's behind your ankle swelling, and what can you do about it?
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Learn the true causes of swollen feet, and how diabetes can worsen this painful condition. And stick around to discover 6 proven methods for reversing diabetes-related ankle swelling.

1) Peripheral edema - or swelling in extremities due to a build-up of fluid in between cells, can be a side effect of taking certain pharmaceuticals meant to treat symptoms of diabetes. Certain diabetes medications, including TZDs and sulfonylureas, have been found to increase the risk of fluid retention in hands and feet.

2) Prolonged exposure to high levels of glucose in the bloodstream damages nerves throughout the body, including in the legs. Over time, this can lead to diabetic neuropathy. This condition can lead to INFLAMMATION, which may compromise the function of the LYMPHATIC SYSTEM - a part of your immune system that works to maintain fluid balance in tissues. So lymphatic dysfunction can impair the removal of fluid from your hands and feet.

3) Caffeine intake can disrupt your balance of ELECTROLYTES, especially sodium and potassium, which may create fluid build-up in legs. And like some medications, caffeine and alcohol have both been found to create VASODILATION, which can lead to increased capillary permeability - which allows fluid to leak into surrounding tissues.

4) Diabetes can lead to conditions like NON-ALCOHOLIC FATTY LIVER DISEASE and CIRRHOSIS. This may result in impaired protein synthesis – which, in turn, can lead to fluid imbalances and a reduction in levels of ALBUMIN. Low levels of this protein can lead to fluid leakage in tissues.

5) Complications to your MICROVASCULAR SYSTEM can significantly impact your fluid balance, potentially leading to peripheral edema. Damage to this network of micro vessels can disrupt the delicate balance between fluid filtration and fluid drainage in your skin and subcutaneous tissues.

6) High blood sugar and increased insulin resistance have both been shown to induce the release of pro-inflammatory CYTOKINES, which can contribute to a sustained inflammatory state in your body. That can damage the endothelial lining of your blood vessels, potentially allowing fluids to leak into tissues around your ankles.

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