The serotonin hypothesis (or in popular terms, serotonin theory) has been an influential idea since the discovery of the first antidepressant drugs in the 1950s. A recent review article has supposedly debunked the idea that serotonin has anything to do with depression. In this video, I will give my pharmacologists perspective on the topic.

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Additional reading:

The serotonin theory of depression: a systematic umbrella review of the evidence
PMID: 35854107 DOI: 10.1038/s41380-022-01661-0

Expert reaction to a review paper on the ‘serotonin theory of depression’
https://www.sciencemediacentre.org/ex...

Background on antidepressant research
https://helda.helsinki.fi/handle/1013...