The U.S. confirms that Iran has fired a barrage of drones toward Israel, marking significant escalation in the Middle East. Britt Clennett reports from Israel, Selina Wang from the White House and Colonel Steve Ganyard offers analysis. Ines de La Cuetara on the deadly rampage erupting at a busy mall in Sydney, Australia; Em Nguyen has the stunning health warning from pharmacists as drug shortages in the U.S. reach an all-time high; and more on tonight’s broadcast of World News Tonight.

00:00 Intro
02:22 Iran launches roughly a hundred drones toward Israel
05:28 President Biden meeting with his national security team in the Situation Room
06:56 How unprecedented is it for Iran to strike within Israel's borders?
08:24 Deadly stabbing rampage at a busy mall in Sydney, Australia
10:30 Severe weather threatens much of the country
11:38 Drug shortages in the U.S. reach an all-time high
13:27 Ohio teen’s family speaking out after he was shot by a police officer
15:24 Four men arrested in connection with the disappearance of two Kansas moms
15:39 Legal setback for Hunter Biden

16:19 Dramatic cable car rescue on a scenic mountain
16:46 Deadly accident at a Honolulu cruise ship terminal

17:19 Dangerous wrong-way chase on a busy highway outside Detroit

17:48 Two firefighters and the eager baby who just couldn't wait to be born

ABC World News Tonight with David Muir delivers the news that matters most. Watch to get the latest news stories and headlines from around the world.

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