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Recently Deepmind made big headlines with its AlphaFold success. Did it really "solve" protein folding? What did actually happen? In this video I explain what the protein folding problem is, why it's important, and what the current situation is.

The protein animation shown at 1 mins 13 seconds goes back to this publication:

Structure of the Cdc48 segregase in the act of unfolding an authentic substrate.
Cooney I, Han H, Stewart MG, Carson RH, Hansen DT, Iwasa JH, Price JC, Hill CP, Shen PS.
Science, 365(6452): 502-505 (2019).
https://doi.org/10.1126/science.aax0486

Reused with permission.

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#science #education #biochemistry

0:00 Intro
0:35 What's the problem?
1:49 Why does it matter?
5:07 How to try and solve it
6:27 The CASP Competition
8:10 Alphafold 2
9:07 What does this mean?
10:42 Sponsor Message