Patient RJ by Jake Rattan, Friend 1 by Matt Hernandez, Food Enjoyer by Lexi Richmond, PA/Friend 4 by Luke Menzies
Mark Rober Hot Ones:    • Mark Rober Gives Up on Science While ...  
Peer Review: Dr Araceli Morga Vera, Dr Yue Wu, Dr Katherine Johns
Spanish translation and dub: Cenzontle Voices Inc, CDMX
Portugese translation and dub: George Frederico
Music by @Lifeformed ► https://lifeformed.bandcamp.com

In-depth (podcast) channel @HemeReview
Secret Channel @BigEmus

Medicine ►    • Medicine  

There's a secret version of this video in 8k:    • A Man Drank 1 Bottle Throat Numbing S...   the music levels were out of whack on that one so I elected to publish this one instead

0:00 Throat Numbing Spray Label
0:14 A Man Swallowed 1 Bottle Throat Numbing Spray While Eating Spicy Food
2:00 haha spray go glug 😳 glug
3:29 The emergency room 🚑 where we are now
4:10 Cyanosis and oxygen saturation
5:05 Arterial blood gas vs oxygen saturation
5:58 ...but something's wrong
6:38 This brings us back to the spray...
7:16 I promise you that stuff you learned in high school chemistry was worth it because it applies here
10:07 What does the throat numbing spray have to do with this?
12:10 ONOO😞- (Biochemical breakdown)
14:49 Throat numbing spray misuse isn't new
15:52 When you misuse the antidote and it becomes a poison itself

Some images by Getty Images

These cases are patients who I, or my colleagues have seen. They are de-identified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet.

References:
Benzocaine-induced Methemoglobinemia. https://www.ncbi.nlm.nih.gov/pmc/arti...

Reported Adverse Event Cases of Methemoglobinemia Associated With Benzocaine Products. https://jamanetwork.com/journals/jama...

Safety Information on Benzocaine-Containing Products. https://www.fda.gov/drugs/postmarket-...

Benzocaine. https://www.cureus.com/articles/68795...

Continuous Methylene Blue Infusions for Treating Recurrent Methemoglobinemia. https://toxandhound.com/toxhound/refr...

Methemoglobinemia https://emcrit.org/ibcc/methemoglobin...

Pulse Oximetry https://emcrit.org/pulmcrit/pulse-oxi...

Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine. https://www.tandfonline.com/doi/abs/1...

Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure. https://pubmed.ncbi.nlm.nih.gov/25211...

A mitochondrial superoxide theory for oxidative stress diseases and aging. https://www.ncbi.nlm.nih.gov/pmc/arti...

4.2 Oxygen Binding: https://chem.libretexts.org/Bookshelv...

Benzocaine Label without Methemoglobinemia warning: https://fda.report/DailyMed/29890aa7-...

Acute Phenol Poisoning: https://www.jstor.org/stable/27720955

Goldfrank's Toxicologic Emergencies 11th Edition Text

Methemoglobinemia. UpToDate. Accessed 01 Feb 2023.