Substantial advances in the treatment of multiple myeloma over the last decade, attributable to novel agents and novel combinations, are leading investigators to challenge the long-standing belief that myeloma is incurable. Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, discusses cure as a goal of therapy rather than disease control, and reinforces the concept of operational cure. This interview took place during the 7th World Congress on Controversies in Multiple Myeloma (COMy), 2021.