Mast cell activation disorders may present as episodic inflammatory symptoms that come and go over time making them difficult to diagnose. These fluctuating symptom patterns include allergic-type responses and non-specific symptoms ranging across the cardiovascular, endocrine, gastrointestinal, dermatologic, and respiratory systems. Chronic diseases and lifestyle choices may influence mast cell dysregulation and overall immune system activation. Identifying potential antecedents and triggers of mast cell activation is an important clinical step for determining the impact of this activation on a patient’s medical condition and for developing a treatment plan that supports both structural integrity and a healthy immune response. On this episode of Pathways to Well-Being, we welcome a pioneer in mast cell disease research, Dr. Lawrence B. Afrin to discuss recent advances in the literature and provide new insights on treating this complex disorder.