Bitten by a vicious "weremole", Muriel transforms into a similar creature under the light of a full moon. As Courage finds the original monster in hopes of a cure, Eustace faces his deranged wife (whom he has mistaken for a mouse) with his brittle wit and trusty mallet.

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Courage is a timid pink dog with paranoia problems. He and his owners live on a farm in the middle of Nowhere... literally. Despite being far away from everything and everyone, that doesn't stop a whole bunch of bizarre adversaries turning up like living nightmares. Courage must overcome his fear and help save his owners, Eustace and Muriel, from ghosts and paranormal spirits living on the farm. Although Muriel loves Courage, Eustace loves to tease him and scare him.