A woman in an open-relationship keeps getting ill and it is up to the team at Princeton-Plainsboro Teaching Hospital to figure out why - turns out that there's many consequences that can come out of participating in sexual acts; Taub for one knows this, too.

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From Season 6 Episode 18 ''Open and Shut'': A woman (Sarah Wayne Callies) in an open relationship becomes ill during a date with her other lover, and House (Hugh Laurie) and his team find her lifestyle as perplexing as her illness. Meanwhile, House tests Wilson's (Robert Seaon Leonard) relationship with Sam (Cynthia Watros).

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