The MGM Grand Garden Arena (originally known as the MGM Grand Garden Special Events Center) is a multi-purpose arena located within the MGM Grand Las Vegas on the Las Vegas Strip.

From its opening in 1993 until the opening of the MGM co-owned T-Mobile Arena in 2016, MGM Grand Garden Arena along with the Thomas & Mack Center were the main sports arenas in the Las Vegas area.

The arena is well known for numerous professional boxing superfights, such as Evander Holyfield vs. Mike Tyson II, Oscar De La Hoya vs. Floyd Mayweather, Oscar De La Hoya vs. Manny Pacquiao, Floyd Mayweather vs. Saúl Álvarez and Floyd Mayweather vs. Manny Pacquiao.

From 1996 to 2000, it hosted wrestling's WCW Halloween Havoc PPV event. The UWF television event Blackjack Brawl was held at the venue in 1994.

As of April 2016, the arena has held 40 Ultimate Fighting Championship events (starting with UFC 34 and most recently UFC 197).

On September 7, 1996, Bruce Seldon vs. Mike Tyson was held here.

On May 2, 2015 Floyd Mayweather Jr defended his world title in a highly anticipated match against fellow superstar Manny Pacquiao. The fight went the distance and Floyd "Money" Mayweather Jr retained his title. The faces of the sold out crowd were fashion and entertainment icons such as hip-hop artist Jay-Z, UFC fighter Ronda Rousey and former NBA basketball player Michael Jordan.

The arena has hosted many editions of WCW Monday Nitro.

In 1994, the Las Vegas Dustdevils, an indoor soccer team in the Continental Indoor Soccer League played one season at the arena. It also previously served through 2015 as the pre-season home for select Los Angeles Kings games against the Colorado Avalanche, Phoenix Coyotes and San Jose Sharks, known as Frozen Fury. Two more games occurred at the new T-Mobile Arena before the launch of the NHL's Vegas Golden Knights.

On October 24, 2014, MGM GGA held an NBA preseason game between the Los Angeles Lakers and the Sacramento Kings.

During the 1990s, the arena served as the site for the WAC women's volleyball tournament. The Professional Bull Riders (PBR) held its annual World Finals event at the MGM Arena from 1994 to 1998 before moving to the Thomas & Mack Center in 1999 and then to T-Mobile Arena in 2016.

On March 13, 2012, it was announced that the Pac-12 Men's Basketball Tournament would take place at the arena from at least 2013 through 2016 and then to T-Mobile Arena in 2017 until 2020.

Beginning in 2014, the MGM Grand Garden Arena will host The MGM Resorts Main Event, an 8-team college basketball tournament held during Monday and Wednesday of Thanksgiving week of NCAA Division I men's basketball season. The MGM Grand Main Event features two four-team brackets, with each team playing two games in Las Vegas. Opening round games are played on campus.

The MGM Grand Garden Arena hosted the Latin Grammy Awards in 2014, 2015 and most recently in 2017.

The venue has also hosted the Academy of Country Music Awards on multiple occasions, including 2018's event which will be the first following the 2017 Las Vegas shooting, which occurred roughly 1 mile away.