National Institute of Mental Health Director Tom Insel changes minds — or should we say, changes brains — about the science of mental health. He has never been satisfied with treatments that help individuals get "better but not well." His tenure at NIMH is marked by groundbreaking findings in the areas of practical clinical trials, autism research, and the role of genetics in mental illness. Insel shares the results of cutting-edge research that supports early identification and prevention of major mental disorders, from autism to schizophrenia, as well as substance use disorders.