Berberine has many important mechanisms. In the current series of talks we are presenting the mechanisms related to the management of Type 2 diabetes mellitus. In the current talk we look at the high level mechanism of how Berberine helps increase the insulin secretion.

Note: cell's depolarization process is intentionally skipped to keep the focus on the potassium channels.

DrBeen: Medical Education Online
https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

URL list from Sunday, Feb. 13, 2023

Berberine is an insulin secretagogue targeting the KCNH6 potassium channel | Nature Communications
https://www.nature.com/articles/s4146...

AMP-activated protein kinase - Wikipedia
https://en.wikipedia.org/wiki/AMP-act...

Frontiers | Cerebral Gluconeogenesis and Diseases
https://www.frontiersin.org/articles/...

Phosphoenolpyruvate carboxykinase - Wikipedia
https://en.wikipedia.org/wiki/Phospho...

Gluconeogenesis - Wikipedia
https://en.wikipedia.org/wiki/Glucone...

Metformin - Wikipedia
https://en.wikipedia.org/wiki/Metformin

Sterol regulatory element-binding protein 1 - Wikipedia
https://en.wikipedia.org/wiki/Sterol_...

The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling - PMC
https://www.ncbi.nlm.nih.gov/pmc/arti...

mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis | PNAS
https://www.pnas.org/doi/10.1073/pnas...

Insulin Signaling Pathway | Antibodies.com
https://www.antibodies.com/insulin-si...

Regulation of SREBP by insulin signaling pathway  | Download Scientific Diagram
https://www.researchgate.net/figure/R...

The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet - PMC
https://www.ncbi.nlm.nih.gov/pmc/arti...

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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.