Various companies are working to settle on other planets. How long would it take and what issues would we face along the way?

Earth-Like Planet Discovered! What You Need To Know -    • Earth-Like Planet Discovered! What Yo...  
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Estimation of a genetically viable population for multigenerational interstellar voyaging
http://www.sciencedirect.com/science/...
"Designing interstellar starships for human migration to exoplanets requires establishing the starship population, which factors into many variables including closed-ecosystem design, architecture, mass and propulsion."

How We Could Visit the Possibly Earth-Like Planet Proxima b
http://www.space.com/33844-proxima-b-...
"A potentially Earth-like planet has been discovered orbiting a star located right next door to the sun. Should humanity try to send a probe there as soon as possible?"

Inbreeding shaped the course of human evolution
https://www.newscientist.com/article/...
"Talk about an inauspicious beginning. For thousands of years our ancestors lived in small, isolated populations, leaving them severely inbred, according to a new genetic analysis. The inbreeding may have caused a host of health problems, and it is likely that small populations were a barrier to the development of complex technologies."

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Special thanks to Emily Calandrelli for hosting and writing this episode of DNews!
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