Dexter and Dee Dee go to South America to catch the legendary chupacabra, which is actually one of Dexter's early experiments that had escaped, though he has forgotten why he had created him.

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Past the vaulted doors lives the smartest boy the world has ever seen, Dexter, boy genius! He's constantly creating dazzling, world-saving inventions in his secret laboratory. His big sister Dee Dee frequently wrecks his experiments. However, he has bigger problems such as his nemesis, Mandark, his brilliant rival at Huber Elementary School. Mom and Dad, of course, have no idea what their little angel is up to.