The NASA Open Science Data Repository (OSDR) embodies and advances NASA's open science vision, revolutionizing open access to space biology data. OSDR started as GeneLab in 2018, and grew substantially with the integration of data from the Ames Life Sciences Data Archive in 2023. Rare and precious space biology datasets that were previously archived are now available for download and analysis by the scientific community. To enhance accessibility, GeneLab collaborated with a diverse scientific community, forming the Analysis Working Group (AWG) of data users in 2018. Over five years, the AWG grew from 20 to 600 members, contributing to over 10 scientific publications. Monthly virtual meetings, workshops, and symposiums fostered a collaborative environment, promoting inclusivity among researchers, students, and industry professionals. This community spawned initiatives like the European Space Agency Topical Team, International Standards for Space Omics Processing (ISSOP), and the COVID-19 International Research Team (COV-IRT). The 2023 Year of Open Science also saw OSDR integrating a massive amount of data from the SpaceX Inspiration-4 mission, one of the first civilian astronaut missions. Making this human data available to the community has and will continue to accelerate our knowledge about spaceflight effects on living systems.