In 2020, robotics company C.E.O. Elias VanDorne reveals Kronos, the supercomputer he has invented to end all wars. Kronos decides that mankind is responsible for all wars and it tries to use robots to kill all humans. VanDorne and Damien Walsh, a colleague, upload themselves into Kronos and watch the destruction. Ninety-seven years later, Andrew, a kind-hearted young man, wakes up in a ruined world. VanDorne and Walsh, still in Kronos, watch Andrew meet Calia, a teenage girl who seeks the last human settlement, the Aurora. Though Calia is first reluctant to let Andrew accompany her, still shaken by a drone attack that resulted in her parents leaving her alone with her fatally wounded sister, the two later fall in love. Unbeknownst to them, VanDorne and Walsh are monitoring the pair, hoping that they would show them the way to Aurora.

During their travels, they come across a pack of marauders, who manage to capture Andrew, forcing Calia to abandon him, only for her to return later to attempt to free him. When Calia is attacked and sexually harassed by some of the marauders, Andrew instinctively demonstrates superhuman strength and resilience, easily defeating the thugs and surviving being cut down by their leader, who is fatally stabbed by Calia. Calia finds machinery in one of Andrew's wounds, causing her to become upset and abandon Andrew. The two are then captured and brought to Walsh, who tells them that Andrew, the first in a new generation of machines, was designed to kill any remaining humans. Andrew the machine has his long-dead eponym's memories, which Walsh makes Andrew search for clues about Aurora’s location. Andrew instead envisions his mother, Veronica, who reminds him that he's still her loving son. This helps Andrew the machine identify with his eponymous self. Andrew overrides Walsh's program and escapes with Calia.

Andrew and Calia spot the lights of what they believe to be Aurora, but only find a robot city. Damien concludes that Aurora was a myth after all, ordering his robot drones to kill them and all remaining humans, having kept the few scavengers and marauders alive only to follow them to Aurora. As the robots start carpet bombing the few remaining humans, Andrew and Calia flee underground, finding a high-tech room. Reacting to the presence of a human, the room reveals itself to be the control room of a space ship which sets course for Aurora - a distant planet rather than an Earth-based settlement. With Kronos' bombs approaching, Andrew and Calia activate the ship's hyperdrive to escape.

Now possessing the location of Aurora, Elias betrays and kills Damien. Andrew and Calia arrive at Aurora which proves to be a lush planet with futuristic cities. In a voiceover, Calia proclaims that Kronos will come after Aurora, but that with Andrew, a machine that may be more human than anyone else, they stand a chance.