Viruses must enter cells to reproduce, but they are too large to simply pass through the membrane of the cell. To enter cells, viruses bind receptors on the plasma membrane and release their genome either at the cell surface or within the cell. In this lecture we discuss how virus particles attach to cell receptors, the triggers for genome release from icosahedral and enveloped viruses, and how membrane fusion is regulated.

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I’m Vincent Racaniello, Earth’s Virology Professor, and I believe that education should be free.

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