In this comprehensive video on pharmacology, we delve into the fascinating world of drugs used to treat osteoporosis. If you're curious about how bisphosphonates, RANKL inhibitors, selective estrogen receptor modulators (SERMs), parathyroid hormone (PTH) analogs, and sclerostin inhibitors work to combat this debilitating condition, you're in the right place!

Understanding the mechanisms of action behind these osteoporosis drugs is crucial for both healthcare professionals and individuals seeking to educate themselves. Join us as we break down each class of medication, exploring their unique roles in promoting bone health and preventing fractures.

🔬 Bisphosphonates: Discover how these widely prescribed drugs inhibit bone resorption, effectively strengthening bones and reducing the risk of fractures.

🔬 RANKL Inhibitors: Learn about the targeted approach of RANKL inhibitors, which interfere with the signaling pathway responsible for bone breakdown, ultimately leading to increased bone density.

🔬 Selective Estrogen Receptor Modulators (SERMs): Uncover how SERMs work by binding to estrogen receptors, offering estrogen-like effects on bone density while minimizing estrogen-related risks.

🔬 Parathyroid Hormone (PTH) Analogs: Explore the fascinating concept of using synthetic PTH analogs to stimulate bone formation, enhancing bone strength and reducing the likelihood of fractures.

🔬 Sclerostin Inhibitors: Delve into the role of sclerostin, a protein that inhibits bone formation, and learn how the novel class of sclerostin inhibitors helps to increase bone density by neutralizing its effects.

Whether you're a healthcare professional, a student, or simply interested in learning about osteoporosis treatment options, this video will empower you with the knowledge you need.

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0:00 Intro - Osteoclasts & Osteoblasts
00:45 Bone Remodeling Process
4:40 RANKL inhibitors
5:58 Bisphosphonates
7:18 Selective Estrogen Receptor Modulators
8:35 Parathyroid Hormone Analogs
9:57 Sclerostin Inhibitors
10:54 Summary