Dr. Peter Attia on Longevity Drugs, Alzheimer's Disease, and The 3 Most Important Levers to Pull | Brought to you by Athletic Greens all-in-one supplement https://athleticgreens.com/tim , Oura smart ring wearable https://ouraring.com/, and Eight Sleep’s Pod Pro Cover sleeping solution for dynamic cooling and heating https://www.eightsleep.com/tim.

Dr. Peter Attia (PeterAttiaMD.com) is a former ultra-endurance athlete (e.g., swimming races of 25 miles), a compulsive self-experimenter, and one of the most fascinating human beings I know. He is one of my go-to doctors for anything performance or longevity-related.

But here is his official bio to do him justice:

Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (how long you live), while simultaneously improving healthspan (how well you live).

Peter trained for five years at the Johns Hopkins Hospital in general surgery, where he was the recipient of several prestigious awards, including Resident of the Year, and the author of a comprehensive review of general surgery. He also spent two years at NIH as a surgical oncology fellow at the National Cancer Institute where his research focused on immune-based therapies for melanoma. He has since been mentored by some of the most experienced and innovative lipidologists, endocrinologists, gynecologists, sleep physiologists, and longevity scientists in the United States and Canada.

Peter also hosts The Drive, a weekly, deep-dive podcast focusing on maximizing longevity and all that goes into that, from physical to cognitive to emotional health. It features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Subscribe on Apple Podcasts, Spotify, Overcast, or wherever you listen to podcasts.

Please enjoy!

00:00 Start
03:29 Liquid Biopsy
15:50 Four pillars of exercise
19:22 Posture
27:40 Zone Two training
29:55 Diets, fasting, nutrition
40:10 “3 levers” framework
44:36 Muscle loss when fasting
46:38 Psilocybin and MDMA
01:11:01 Cholesterol and ApoB
01:28:42 Rapamycin and lifespan
01:56:30 Sauna benefits
02:01:00 Preferred Zone Two method
02:04:30 Effectiveness of Semaglutide
02:11:32 Resources and recommendations
02:14:06 Texas—the good, the painful
02:18:39 Zone Two deep dive

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