Mulholland Drive is a street and road in the eastern Santa Monica Mountains of Southern California. It is named after pioneering Los Angeles civil engineer William Mulholland. The western rural portion in Los Angeles and Ventura Counties is named Mulholland Highway. The road is featured in innumerable movies, songs, and novels. David Lynch, whose film Mulholland Drive is suffused with the atmosphere of the road, once said that one can feel "the history of Hollywood" on it.

The 21-mile long mostly two-lane, minor arterial road loosely follows the ridgeline of the eastern Santa Monica Mountains and the Hollywood Hills, connecting two sections of U.S. Route 101, and crossing Sepulveda Boulevard, Beverly Glen Boulevard, Coldwater Canyon, Laurel Canyon Boulevard, Nichols Canyon Road, and Outpost Drive.

The road offers spectacular view of the Los Angeles Basin, the San Fernando Valley, and the Hollywood Sign.

Mulholland Drive is home to some of the most exclusive and most expensive homes in the world. Many of these homes are set back from the road and offer outstanding views of downtown Los Angeles. Celebrities such as Jack Nicholson, Sylvester Stallone, Justin Timberlake, Eric Stoltz, Jessica Biel, Paris Hilton and Reese Witherspoon all live nearby.