Every year I compile what I think were some important contributions to longevity research. Here is my list for 2023.

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Intro - 00:00

What causes aging? - 00:32
Hallmarks Of Aging: An Expanding Universe
The DREAM Complex Functions As Conserved Master Regulator Of Somatic DNA-Repair Capacities

Biomarkers - 02:00
The Aging Biomarker Consortium Represents A New Era For Aging Research In China
Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock
A Foundation Model For Generalizable Disease Detection From Retinal Images

Cellular reprogramming - 04:30
Chemically induced reprogramming to reverse cellular aging
Loss of epigenetic information as a cause of mammalian aging
In vivo reprogramming leads to premature death linked to hepatic and intestinal failure

Lifespan extension - 07:30
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
Taurine deficiency as a driver of aging
Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice
Optogenetic Rejuvenation Of Mitochondrial Membrane Potential Extends C. Elegans Lifespan
Reversal Of Biological Age In Multiple Rat Organs By Young Porcine Plasma Fraction
Multi-Omic Rejuvenation And Life Span Extension On Exposure To Youthful Circulation

Biotechnology - 13:50
Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues
Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy

Why we age - 15:15
Ageing as a software design flaw
The Longevity Bottleneck Hypothesis: Could Dinosaurs Have Shaped Ageing In Present‐Day Mammals?
Reconsidering Life History Theory Amid Infectious Diseases
Blood Group A Enhances SARS-CoV-2 Infection

What's next? - 16:50

There are many items missing from this list - these are only the papers I found time to read. Please post below any I missed!

ICYMI

2022 longevity papers

2021 longevity papers

Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.

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