In this recorded Cardiology Grand Rounds presentation, Professor Michel Haïssaguerre, Chief of Cardiac Electrophysiology & Simulation at Olivier Hospital, Bordeaux & founder/Director of the Liryc Institute delves into ablation of atrial fibrillation (AF) and ventricular fibrillation (VF), the most complex cardiac arrhythmias. Key topics covered by Professor Haïssaguerre include historical ablation approaches, pivotal discovery of AF triggers in pulmonary veins, differences between paroxysmal v. persistent AF, involvement of Purkinje fibers in VF onset, identification of myocardial scar regions and rotors driving VF; and progress in curative VF ablation. The lecture concludes by breaking down poignant takeaways that include discrete triggers/drivers underlying fibrillation complexity, junctions between scar and healthy tissue housing rotors, VFs linked to Purkinje system & subclinical lesions causing unexplained sudden death.

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Learning Objectives:
1. Review traditional ablation approaches.
2. Differentiate between paroxysmal v. persistent atrial fibrillation.
3. Discuss Purkinje involvement in ventricular fibrillation.
4. Adopt early rhythm control therapy for atrial fibrillation to reduce progression
5. Expand catheter ablation therapy to additional ventricular fibrillation patients

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