Tuberculosis is the second leading cause of death by infectious disease in the world right now. Number one has only existed for a year and a half.

While much more is known about the former, including effective treatments, the world still struggles to alleviate its burden. Part of the problem is how new technology, such as IGRA and NAAT, made pathways more complex, even if more effective.

In this video, I’ll review the evidence and try to clear up everything you need to know about latent TB: as a practitioner or a student. In my years of practice in Brazil, and even in the United States, I often saw people with suspicion for latent or active TB. Distilling the main concepts and relevant evidence for it will hopefully make it easier for you as well.
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References:
-Theme song: In the Hall of the Mountain King - Edvard Grieg
-tb deaths https://www.who.int/hiv/mediacentre/n...
-UK guidelines, world incidence map https://www.bmj.com/content/352/bmj.h...
-latent TB to active risk ‘82 study https://www.ncbi.nlm.nih.gov/pmc/arti...
-latent tb cdc https://www.cdc.gov/tb/publications/f...
-tst image from cdc https://commons.wikimedia.org/w/index...
-tst induration https://commons.wikimedia.org/wiki/Fi...
-isoniazide hepatitis risk https://pubmed.ncbi.nlm.nih.gov/10086...
-discontinue TB precautions cdc.gov/mmwr/preview/mmwrhtml/rr5417a1.htm
-IGRA principles https://www.ncbi.nlm.nih.gov/pmc/arti...
-dx latent TB adults https://www.uptodate.com/contents/app...
-WHO 2014 dx TB in children https://apps.who.int/iris/bitstream/h...
-WHO 2006 dx TB children https://www.ingentaconnect.com/conten...
-study rifampin isoniazide https://academic.oup.com/cid/article/...
-study rifapentine isoniazide https://www.nejm.org/doi/10.1056/NEJM...
-study rifampin solo https://www.nejm.org/doi/10.1056/NEJM...
childhood exposure, risk of invasive TB https://pubmed.ncbi.nlm.nih.gov/15141...
-WHO latent TB infection https://apps.who.int/iris/bitstream/h...
-TST cutoffs paper https://www.ncbi.nlm.nih.gov/pmc/arti...
-simplify gif https://imgur.com/gallery/kHzlD/comme...
-GIF indecisive https://drivingcoursereviews.com/wp-c...
-GIF its a lot https://giphy.com/gifs/thebachelorett...
-GIF mix n match   / 119838040063832277  
-eradication smallpox https://www.cdc.gov/smallpox/history/...
-eradication polio https://www.thestar.com/news/insight/...
-kid thumbs up gif https://giphy.com/gifs/retro-thumbs-u...
-boo gif https://media.giphy.com/media/8caqKmP...