This video demonstrates surfactant instillation into the trachea via a thin catheter (the Hobart method) in a preterm infant manikin. This is the technique of minimally invasive surfactant therapy (MIST) that was used as the active therapy in the OPTIMIST-A randomized clinical trial. The study compared MIST against sham treatment for preterm infants with respiratory distress syndrome. It found that MIST did not result in a statistically significant reduction in the combined outcome of death or bronchopulmonary dysplasia.

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