When Eddie Brock's Venom symbiote soon returned to be bonded again, allowing Venom to escape prison, the symbiote left its offspring in the cell; due to its alien mindset, the symbiote felt no emotional attachment to its offspring, regarding it as insignificant, and thus never communicated its existence to Brock via their telepathic link. The new symbiote then bonded with Brock's cellmate Cletus Kasady through a cut on his hand, transforming him into Carnage. The bond between the Carnage symbiote and Kasady was stronger than the bond between Brock and the Venom symbiote. Cletus Kasady was also a serial killer and thought of as insane. As a result, Carnage is far more violent, powerful, and deadly than Venom. Kasady and the symbiote would then be a main antagonist in "Maximum Carnage" and Kasady would continually be the most recurring character to use the Carnage symbiote in many publications.

List of games:

1. The Amazing Spider-Man 2 (1992)
2. Spider-Man and the X-Men in Arcade's Revenge (1992)
3. Spider-Man and Venom: Maximum Carnage (1994)
4. The Amazing Spider-Man: Lethal Foes (1995)
5. Venom/Spider-Man: Separation Anxiety (1995)
6. Spider-Man (2000)
7. Spider-Man 2: Enter Electro (2001)
8. Ultimate Spider-Man (2005)
9. Spider-Man: Friend or Foe. PSP (2007)
10. Marvel: Ultimate Alliance 2 (2009)
11. Spider-Man: Shattered Dimensions (2010)
12. Pinball FX2 (2010)
13. Marvel Super Hero Squad Online (2011)
14. Marvel Avengers Alliance (2012)
15. Marvel Heroes (2013)
16. Marvel Puzzle Quest (2013)
17. Lego Marvel Super Heroes (2013)
18. The Amazing Spider-Man 2 (2014)
19. Spider-Man Unlimited (2014)
20. Marvel: Contest of Champions (2014)
21. Marvel: Future Fight (2015)
22. Marvel Avengers Academy (2016)
23. Lego Marvel Super Heroes 2 (2017)
24. Marvel Strike Force (2018)
25. Marvel Battle Lines (2018)