Protein synthesis inhibitors antibiotics targets various steps in ribosomal protein synthesis.
Bacterial ribosome is composed of two subunits; 30s and 50s subunits that unite together to form 70s complex. Tetracycline inhibits the binding of tRNA to 30s subunit. Aminoglycosides bind to and distort 30s subunit. Chloramphenicol inhibit the elongation of amino acids sequences. Macrolides inhibit the sliding of mRNA in the ribosome.