The hypothesis of this patient being too kind for his own good is proven when overcoming his illness makes his personality change drastically... and not in a good way.

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From Season 4 Episode 13 ''No More Mr. Nice Guy'': House suspects an emergency room patient has a bigger problem than the E.R. initially diagnosed based on the fact that the patient is too nice. A skeptical House questions the patient's sunny disposition as the team tries to get to the bottom of his illness, but disagrees with House that niceness is a symptom. Meanwhile, House is at odds with Wilson's girlfriend, Amber about how much time they each get to spend with Wilson, and Cuddy demands House give his team performance reviews.

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