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Understanding Aging & Disease and How They're Related:    • Understanding Aging & Disease and How...  

Biological age—that is, how old your cells and tissues are based on physiological function—is a multifaceted and intricate concept that transcends numerical representation. Unlike chronological age, which refers simply to the number of years you have been alive, the concept of biological age delves into the dynamic interplay between physiological processes, genetic predispositions, and environmental influences that collectively shape an individual's health trajectory. Geroscientists are currently studying the biological mechanisms that might impact your biological aging rate and perhaps reverse some of the functional declines that accompany aging.

0:00 Trailer
0:53 Some important definitions
2:33 Biological age and automobiles
4:42 3 core concepts
5:26 Variation in biological aging rate determines the difference between chronological age and biological age
11:15 Why biological aging is an important concept to internalize
11:49 Biological aging rate can vary dramatically within and between species
15:55 Health and mortality risk are both strongly related to, but not equivalent to, biological age
17:40 Reversing aging
22:13 Takehome and recap of the 3 core concepts

Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

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Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful!