Yale-Mayo Clinic CERSI Scholar Virtual Research Seminar 2023

During this seminar, the CERSI Scholars presented the results of their regulatory science research projects, including studies examining pharmaceutical innovation, medical product safety, leveraging advanced analytics, and much more. This seminar was also opened with a keynote address by RDML Richardae Araojo, PharmD, MS, Associate Commissioner for Minority Health and Director of the Office of Minority Health and Health Equity. Please see below for the full agenda.

Introduction
Joseph Ross, MD, MHS, Molly Jeffery, PhD (Yale-Mayo Clinic CERSI) and Jason Schwartz, PhD (Yale School of Public Health)

Keynote Address
“FDA Office of Minority Health and Health Equity: Working to Address Health Disparities” (RDML Richardae Araojo, PharmD, MS, Associate Commissioner for Minority Health and Director of the Office of Minority Health and Health Equity)

Scholar Presentations
Session 1:
Barriers and Facilitators to Trustworthy and Ethical AI-enabled Medical Care: Patient and Healthcare Provider Perspectives (Maryam Mooghali, Yale)
Natural Language Processing (NLP) Approaches for Robust Medical Device Safety Surveillance (Susmitha Wunnava, Harvard)
A Machine Learning, Phenomapping Strategy for Adaptive Predictive Enrichment in Randomized Controlled Trials (Evangelos Oikonomou, Yale)
How to Implement a Risk-based Regulatory Framework for Electronic Health Record (Arnaldo Suba Garcia, JHU)

Session 2:
Examining the Preferences of Adults with Depression on Psychotropic Polypharmacy and Healthcare Providers for Pharmacogenomic Testing at Mayo Clinic
(Dan Kelleher, Mayo Clinic)
Physicians’ Attitudes Toward Clinical Implementation of Pharmacogenomics (Ye (Julia) Zhu, Mayo Clinic)
Understanding the Impact of Demographics and Socioeconomic Parameters on Treatment Selection in Type 2 Diabetes (Jaysón Davidson, UCSF)
Systematic Review of Research Studies that Examined the Reliability of a Surrogate Endpoint as Compared to a Clinical Outcome Measure in Chronic Diseases (Samuel Yoon, Yale)
A Causal Inference Framework for Spatial Confounding (Brian Gilbert, JHU)

Session 3:
Concordance of the Clinical Trials Supporting Regulatory Approval for Factor Xa Inhibitors Across Major Regulatory Agencies
(Tianna Zhou, Yale)
Regulatory Intelligence as a Business Partner (Angela Yu, JHU)
Probability of Success of Gene and Cell Therapy Projects (Magdi Elsallab, Harvard)
Informational Quality in Television Advertising for Prescription Drugs
with FDA “Breakthrough Designation”
(Neeraj Patel, Yale)

Session 4:
Detecting Electronic Signatures of Redox-based Antibody Modification (Dana Motabar, UMD)
Augmentation of Cyclophosphamide Based Chemotherapy Through CYP2B6 Induction (Ritika Kurian, UMD)
Bone Disease Modifying Agents in Multiple Myeloma: An Updated Systematic Review and Network Meta-Analysis
(Alana Munger & Wei Cheng, Yale)
Develop Anti-Senescence Therapies for Anthracycline-Induced Cardiotoxicity
via Zebrafish Genetics (Maryam Moossavi, Mayo Clinic)