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VIDEO SUMMARY
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COMT helps breakdown catecholamines like norepinephrine, epinephrine, and dopamine. In addition, it helps break down estrogen.

A COMT polymorphism (COMT Val158Met) can slow COMT down which increase susceptibility to higher norepinephrine, dopamine, or estrogen levels.

SAMe and Magnesium are the cofactors for COMT. Some people feel better when taking SAMe and some do better with hydroxocobalamin.

It has to do with how their methylation cycle is working - and also downstream nutrients. One must support downstream - and also upstream prior to giving certain nutrients - especially COMT.

I've seen patients do VERY well with SAMe and others horribly.

Understanding their biochemistry and genetic makeup - and history - is needed. One needs all of this information.

One cannot treat a gene in ISOLATION. It's not recommended.


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