OpenSAFELY

https://opensafely.org

New secure analytics platform

Electronic health records in the NHS

Created to deliver urgent results during the COVID-19 emergency

Analyses across more than 24 million patients

Full pseudonymised primary care NHS records

More to follow shortly

Open for security review

Scientific review

Secure environments

Trusted analysts

Large scale computation

Near real-time

Analyses in just five weeks from project start.

More accuracy than any previous analyses by an order of magnitude

Big data

Primary care data

Sufficient statistical power

Associations with specific medications and medical conditions

Early during the pandemic

Save lives by modifying patient, clinician, and population behaviour

Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform

Lancet, 5th November, MRC

https://www.thelancet.com/journals/la...

Hydroxychloroquine

Pre¬exposure (as opposed to post¬exposure) prophylactic

Inhibit entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into epithelial cells in vitro

No evidence of reduced mortality when treating patients with COVID-19

Methods

Observational

Population-based cohort study

Approximately 40% of the general population in England

Association between ongoing use before COVID-19

Compared with non-users of hydroxychloroquine

Risk of COVID-19 mortality

People with rheumatoid arthritis or systemic lupus erythematosus

n = 194, 637 with rheumatoid arthritis or systemic lupus erythematosus

n = 30, 569 received two or more prescriptions of hydroxychloroquine

March 1 and July 13, 2020

547 deaths

Users (n= 30,569)

70 deaths

IFR = 0.23%

Non – users (n = 164,068)

IFR = 0.22%

An absolute difference of 0·008%
Accounting for age, sex, ethnicity, use of other immunosuppressive drugs, and geographical
region
No association with COVID-19 mortality was observed

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