Clindamycin | Erythromycin | Chloramphenicol | MOA & Clinical Correlations🩺

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▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
00:00:00 Introduction and overview of lecture
00:01:29 Overview of similarities between Clindamycin, Macrolide and chloramphenicol
00:02:17 Clindamycin, macrolide (Erythromycin) and chloramphenicol work as protein synthesis inhibitors
00:02:29 MOA of clindamycin, macrolide (Erythromycin) and chloramphenicol on Bacterial Ribosomes
00:02:44 MOA of clindamycin, macrolide (Erythromycin) and chloramphenicol on larger 50s ribosomal subunit
00:03:28 Action of clindamycin , macrolide (Erythromycin) and Chloramphenicol on 23s Ribosomal RNA
00:05:55 Summary of above 4 similarities in the MOA of Clindamycin , Macrolide (Erythromycin) and Chloramphenicol
00:06:27 MOA of Clindamycin, Macrolide (Erythromycin) and Chloramphenicol on Ribozyme
00:07:01 What is Peptidyl Transferase?
00:07:57 Summary of all above similarities between Clindamycin, Macrolide (Erythromycin) and Chloramphenicol
00:09:26 Detailed explanation on the functions of Peptidyl Transferase
00:22:08 Transpeptidation and Ribosomal Translocation
00:22:57 Peptide chain elongation
00:26:31 How Clindamycin, Macrolide (Erythromycin) and chloramphenicol inhibit the protein synthesis by inhibiting the chain elongation process?
00:28:19 Summary of similarities between Clindamycin, Macrolide (Erythromycin) and Chloramphenicol
00:31:46 MOA; Clindamycin
00:39:56 MOA; Clindamycin as bacteriostatic and bactericidal
00:52:14 Summary of MOA of Clindamycin
00:53:32 MOA; Macrolides (Erythromycin)
00:59:18 MOA; Chloramphenicol binding site.
01:00:55 MOA; Comparison of binding site of clindamycin vs macrolide vs chloramphenicol.
01:01:30 MOA; Chloramphenicol.
01:04:00 Chloramphenicol; Adverse effects.
01:06:55 Why clindamycin and macrolide (Erythromycin) don’t produce gray baby syndrome?
01:15:35 Clinical co-relation; Competitive Inhibition; Why clindamycin and erythromycin are not used together for a treatment of any infection?
01:18:40 Summary of role of clindamycin in TSS.
01:19:30 Clinical co-relation; Cross resistance.
01:20:05 Mechanism of resistance involving the changes at binding site, 23s rRNA.
01:20:30 Mechanism#1; Mutant ribosomal protein.
01:22:00 Mechanism#2; Mutation of adenine group at target site, 23s rRNA.
01:22:55 Mechanism#3; Methylation of adenine group at target site, 23s rRNA.
01:25:50 Clinical co-relation; Cross resistance because of erm genes.
01:31:25 Clinical co-relation; post-antibiotic effect in relation to clindamycin, erythromycin
01:38:26 Secondary effect#1; Reduced quantity of proteins
01:38:32 Secondary effect#2; Distorted proteins.
01:38:45 Bacteriostatic action/ Bactericidal action
01:39:28 Surface bacterial proteins altered; Decrease adherence of bacteria.
01:42:40 Excellent choice for abscesses produced by the susceptible bacteria.
01:43:05 Penetration of drug; Bones.
01:43:25 Penetration of drug; Can’t cross BBB.
01:43:45 Summary of all effects produced by clindamycin.
01:44:45 Black box warning for Clindamycin.
01:45:35 Pathogenesis of Pseudomembranous colitis.
01:47:25 Risk factors for Pseudomembranous colitis.
01:47:55 Directions to be given to the patient while prescribing clindamycin.
01:48:20 Treatment for C. diff colitis.
01:49:40 Summary of Black box warning for Clindamycin.
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