Link to free download of my 2 textbooks

http://159.69.48.3/

Physiology book in hard copy
https://www.ebay.co.uk/itm/1547704527...

Pathophysiology book in hard copy
https://www.ebay.co.uk/itm/1547704517...

US variants data

https://covid.cdc.gov/covid-data-trac...

https://www.nytimes.com/interactive/2...

US omicron history

November 29

Index patient, 48 year old unvaccinated man, Nigeria

Nebraska, 6 people diagnosed by PCR and genomic sequencing

Onset was 73 hours (range = 33–75 hours)

Incubation period

https://www.cdc.gov/mmwr/volumes/70/w...

Original version, five days

The Delta variant, four days

Omicron, 2 to 3 days

Viral Load

https://www.nejm.org/doi/full/10.1056...

Alpha and Delta variants

Peak viral load 3 days after infection

Clear the virus about six days after that

Infectious viral load in unvaccinated and vaccinated patients infected with SARS-CoV-2 WT, Delta and Omicron

https://www.medrxiv.org/content/10.11...

Omicron and Delta produced similar levels of infectious virus

Infections a day shorter with omicron compared to delta

Omicron infects upper airways as opposed to lungs

Omicron antibodies neutralise delta virus

Offshoot of Omicron variant, England

https://assets.publishing.service.gov...

https://www.theguardian.com/world/liv...

BA.2 may be even more contagious than original omicron

UK Health Security Agency

Designating BA.2 a variant under investigation

increasing numbers of BA.2 sequences identified both domestically and internationally

May have an increased growth rate over BA.1

Vaccine effectiveness with omicron

https://assets.publishing.service.gov...

After a 2-dose primary course of vaccination

Vaccine protection against mild disease has largely disappeared by 20 weeks after vaccination

After a booster dose

Protection initially increases to around 65 to 70%
but drops to 45 to 50% from 10+ weeks

Therefore

It is therefore likely that current vaccines offer limited long-term protection against infection or transmission.

Protection against severe disease

Vaccine effectiveness against hospitalisation is estimated at 92%

and remains high at 83% 10+ weeks after the booster dose

John’s booster

20th November

So my protection against hospitalisation goes down from 92% to 83% by soon